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In this book, the authors explore how gene-silencing methodology has been successfully applied as therapeutic tool against metabolic disorders, cancer, and infectious diseases. This tool has also been successfully used to improve crops resistance against plant pathogens. In contrast to conventional knock-out mutagenesis techniques, the “gene-silencing” vectors that allow the study of functions of genes whose complete knock-out would otherwise be lethal to the plant. This book combines reliable RNAi protocols for a variety of species with discussion of strategies for the effective design of experiments using this important new technique that is changing the way experimental science is done.
